人声带组织在实验室培养成功 有望让患者重新发声

?

& amp; nbsp & amp; nbsp & amp; nbsp & amp; nbsp human vocal cord tissue was successfully cultured in laboratory

& nbsp & amp; nbsp & amp; nbsp & amp; nbsp & amp; nbsp is expected to make patients vocalize again

& nbsp & amp; nbsp & amp; nbsp & amp; nbsp & amp; nbsp & amp; nbsp science and technology daily, Beijing, September 24 (Reporter Zhang Menglan), according to a medical research published by British magazine《自然通讯》on the 24th, a three-dimensional model of human vocal cord tissue (i.e. mucosa) was developed by the American team in the laboratory. The model can be used to study drugs and therapies related to vocal cord diseases or lesions.

& Am; nbsp& nbsp& nbsp& nbsp& nbsp& nbsp vocal cord vibration function requires it to be flexible enough, vibration characteristics of hundreds of times per second also requires it to be strong enough, so human vocal cord is a very "delicate" system, which has been extremely difficult to replicate. However, the vocal cords are susceptible to chronic inflammation, mainly caused by environmental damage, including cigarettes, allergens or infections. Because extracting cell samples from healthy vocal cords can cause irreversible damage, it has been a long-standing problem for scientists to study vocal cords diseases and repair strategies.

& On the basis of previous studies on mice, human induced pluripotent stem cells (hiPSC) were extracted from vocal cord epithelial cells by using amp; nbsp & amp; nbsp & amp; nbsp & amp; nbsp & amp; nbsp. This time, Susan Sabat, a scientist at the University of Wisconsin, Madison, and his colleagues. Studies have shown that hiPSC-derived vocal cord tissue is genetically and morphologically similar to natural human vocal cord mucosa.

&nbsp&nbsp&nbsp&nbsp当暴露在烟雾中时,该组织会表现出在人喉中发现的反应,即炎症。研究团队随后将该组织在5%的香烟烟雾提取物中暴露了一周的时间,观察是否会诱导出与烟雾相关的黏膜炎症。结果显示,烟雾会导致黏膜炎症以及细胞类型的异常重塑,影响上皮屏障结构。

&nbsp&nbsp&nbsp&nbsp研究人员表示,声带是人类发音的基础,也是分隔声道和食物饮料进入消化通道的关键分界,并能防止异物进入呼吸道。但此前未有能模仿真正声带组织的技术出现,现在的模拟声带组织,不但是一种很有前景的候选方案,也有望让那些因手术或损伤失去声带的患者重新发声。

&nbsp&nbsp&nbsp&nbsp总编辑圈点

&nbsp&nbsp&nbsp&nbsp声带是最能展现人的思想与内在的器官,它虽然小,却极其不寻常 绝大多数动物,包括除了人以外的其他灵长类动物,都不具备人类控制声带发出复杂声音的本领。因喉部疾病而损坏或摘除声带的患者,都遗憾地丧失人生一项基本体验。好在干细胞疗法提供了希望,或许结构相对简单的声带组织将会是干细胞再生医学成功的首选平台。